Armin Sepp

Armin Sepp

Company: GSK

Job title: Scientific Leader & GSK Fellow, Early Pre-Clinical DMPK Modelling


Modeling the PBPK Parameters of FcRn-Mediated IgG Binding & Recycling 2:30 pm

Two-pore physiologically-based pharmacokinetic (PBPK) models describe the tissue distribution and elimination kinetics of soluble proteins, endogenous or dosed, as function of their size and any biological interactions, including FcRn-mediated recycling, where appropriate A cross-modality/cross-species (mouse to man) PBPK modelling framework has been parametrized to guide and provide insight into biologics drug discovery and mode of…Read more

day: Day One

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