Modeling the PBPK Parameters of FcRn-Mediated IgG Binding & Recycling

Time: 2:30 pm
day: Day One


  • Two-pore physiologically-based pharmacokinetic (PBPK) models describe the tissue distribution and elimination kinetics of soluble proteins, endogenous or dosed, as function of their size and any biological interactions, including FcRn-mediated recycling, where appropriate
  • A cross-modality/cross-species (mouse to man) PBPK modelling framework has been parametrized to guide and provide insight into biologics drug discovery and mode of action, e.g. complement C5-targeting antibodies